Over the past couple of decades the global space community has had a vision of sending humans to Mars – not just for a quick visit, but to have a sustainable presence there.  In order to enable this vision, innovations in communications, navigation, sustainable food production, protective habitation materials, high tech health devices, space weather, and so many other areas must be integrated into operations. This talk will highlight some of the visioneering that will need to be explored and demonstrated to ensure mission success.